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Target
Nuclear receptor ROR-alpha
Ligand
BDBM50448405
Substrate
n/a
Meas. Tech.
ChEMBL_1292855 (CHEMBL3122594)
IC50
1300±n/a nM
Citation
 Toyama, H; Nakamura, M; Nakamura, M; Matsumoto, Y; Nakagomi, M; Hashimoto, Y Development of novel silicon-containing inverse agonists of retinoic acid receptor-related orphan receptors. Bioorg Med Chem 22:1948-59 (2014) [PubMed]  Article 
Target
Name:
Nuclear receptor ROR-alpha
Synonyms:
NR1F1 | Nuclear receptor RZR-alpha | Nuclear receptor subfamily 1 group F member 1 | RAR-related orphan receptor A | RORA | RORA_HUMAN | RZRA | Retinoid-related orphan receptor-alpha
Type:
PROTEIN
Mol. Mass.:
58976.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_101591
Residue:
523
Sequence:
MESAPAAPDPAASEPGSSGADAAAGSRETPLNQESARKSEPPAPVRRQSYSSTSRGISVTKKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
  
Inhibitor
Name:
BDBM50448405
Synonyms:
CHEMBL3121750
Type:
Small organic molecule
Emp. Form.:
C19H25NOSi2
Mol. Mass.:
339.5789
SMILES:
C[Si]1(C)CC[Si](C)(C)c2cc(ccc12)C(=O)Nc1ccccc1
Structure:
Search PDB for entries with ligand similarity: