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Target
Glucokinase regulatory protein
Ligand
BDBM50448562
Substrate
n/a
Meas. Tech.
ChEMBL_1296098 (CHEMBL3131527)
EC50
3990±n/a nM
Citation
 Ashton, KS; Andrews, KL; Bryan, MC; Bryan, MC; Chen, J; Chen, K; Chen, M; Chmait, S; Croghan, M; Cupples, R; Fotsch, C; Helmering, J; Jordan, SR; Kurzeja, RJ; Michelsen, K; Pennington, LD; Poon, SF; Sivits, G; Van, G; Vonderfecht, SL; Wahl, RC; Zhang, J; Lloyd, DJ; Hale, C; St Jean, DJ Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept. J Med Chem 57:309-24 (2014) [PubMed]  Article 
Target
Name:
Glucokinase regulatory protein
Synonyms:
GCKR_RAT | Gckr | Glucokinase regulator
Type:
PROTEIN
Mol. Mass.:
68920.17
Organism:
Rattus norvegicus
Description:
ChEMBL_108045
Residue:
627
Sequence:
MPGTKRYQHVIETPEPGEWELSGYEAAVPITEKSNPLTRNLDKADAEKIVKLLGQCDAEIFQEEGQIVPTYQRLYSESVLTTMLQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVSFNQLMKGLGQKPLYTYLIAGGDRSVVASREQTEDSALHGIEELKKVAAGKKRVVVIGISVGLSAPFVAGQMDYCMDNTAVFLPVLVGFNPVSMARNDPIEDWRSTFRQVAERMQKMQEKQEAFVLNPAIGPEGLSGSSRMKGGGATKILLETLLLAAHKTVDQGVVSSQRCLLEILRTFERAHQVTYSQSSKIATLMKQVGISLEKKGRVHLVGWQTLGIIAIMDGVECIHTFGADFQDIRGFLIGDHSDMFNQKDELTNQGPQFTFSQDDFLTSILPSLTETDTVVFIFTLDDNLTEVQALAERVREKCQNIQALVHSTVGQSLPAPLKKLFPSLISITWPLLFFDYEGTYVQKFQRELSTKWVLNTVSTGAHVLLGKILQNHMLDLRIANSKLFWRALAMLQRFSGQSKARCIESLLQAIHFPQPLSDDVRAAPISCHVQVAHEKEKVIPTALLSLLLRCSISEAKARLSAASSVCEVVRSALSGPGQKRSTQALEDPPACGTLN
  
Inhibitor
Name:
BDBM50448562
Synonyms:
CHEMBL3127348
Type:
Small organic molecule
Emp. Form.:
C22H25F6N3O4S2
Mol. Mass.:
573.572
SMILES:
OC(c1ccc(cc1)N1CCN(C[C@@H]1CN1CCOCC1)S(=O)(=O)c1cccs1)(C(F)(F)F)C(F)(F)F |r|
Structure:
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