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Target
Glucokinase regulatory protein
Ligand
BDBM50448567
Substrate
n/a
Meas. Tech.
ChEMBL_1296099 (CHEMBL3131528)
IC50
1010±n/a nM
Citation
 Ashton, KS; Andrews, KL; Bryan, MC; Bryan, MC; Chen, J; Chen, K; Chen, M; Chmait, S; Croghan, M; Cupples, R; Fotsch, C; Helmering, J; Jordan, SR; Kurzeja, RJ; Michelsen, K; Pennington, LD; Poon, SF; Sivits, G; Van, G; Vonderfecht, SL; Wahl, RC; Zhang, J; Lloyd, DJ; Hale, C; St Jean, DJ Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept. J Med Chem 57:309-24 (2014) [PubMed]  Article 
Target
Name:
Glucokinase regulatory protein
Synonyms:
GCKR | GCKR_HUMAN | GKRP | Glucokinase regulator
Type:
PROTEIN
Mol. Mass.:
68685.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_103091
Residue:
625
Sequence:
MPGTKRFQHVIETPEPGKWELSGYEAAVPITEKSNPLTQDLDKADAENIVRLLGQCDAEIFQEEGQALSTYQRLYSESILTTMVQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVSFNQLMKGLGQKPLYTYLIAGGDRSVVASREGTEDSALHGIEELKKVAAGKKRVIVIGISVGLSAPFVAGQMDCCMNNTAVFLPVLVGFNPVSMARNDPIEDWSSTFRQVAERMQKMQEKQKAFVLNPAIGPEGLSGSSRMKGGSATKILLETLLLAAHKTVDQGIAASQRCLLEILRTFERAHQVTYSQSPKIATLMKSVSTSLEKKGHVYLVGWQTLGIIAIMDGVECIHTFGADFRDVRGFLIGDHSDMFNQKAELTNQGPQFTFSQEDFLTSILPSLTEIDTVVFIFTLDDNLTEVQTIVEQVKEKTNHIQALAHSTVGQTLPIPLKKLFPSIISITWPLLFFEYEGNFIQKFQRELSTKWVLNTVSTGAHVLLGKILQNHMLDLRISNSKLFWRALAMLQRFSGQSKARCIESLLRAIHFPQPLSDDIRAAPISCHVQVAHEKEQVIPIALLSLLFRCSITEAQAHLAAAPSVCEAVRSALAGPGQKRTADPLEILEPDVQ
  
Inhibitor
Name:
BDBM50448567
Synonyms:
CHEMBL3127343
Type:
Small organic molecule
Emp. Form.:
C25H24F6N2O3S2
Mol. Mass.:
578.59
SMILES:
Cc1cccc(CC2CN(CCN2c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2cccs2)c1
Structure:
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