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Target
Presequence protease, mitochondrial
Ligand
BDBM50449405
Substrate
n/a
Meas. Tech.
ChEMBL_1294273 (CHEMBL3128915)
EC50
12±n/a nM
Citation
 Vangavaragu, JR; Valasani, KR; Gan, X; Yan, SS Identification of human presequence protease (hPreP) agonists for the treatment of Alzheimer's disease. Eur J Med Chem 76:506-16 (2014) [PubMed]  Article 
Target
Name:
Presequence protease, mitochondrial
Synonyms:
KIAA1104 | MP1 | Metalloprotease 1 | PITRM1 | PREP | PREP_HUMAN | Pitrilysin metalloproteinase 1 | hMP1 | hPreP
Type:
PROTEIN
Mol. Mass.:
117419.85
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108043
Residue:
1037
Sequence:
MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIQ
  
Inhibitor
Name:
BDBM50449405
Synonyms:
CHEMBL3127264
Type:
Small organic molecule
Emp. Form.:
C20H13Br2N3O4
Mol. Mass.:
519.143
SMILES:
Oc1ccc(Br)cc1Cn1c(nc2ccc(cc12)[N+]([O-])=O)-c1cc(Br)ccc1O
Structure:
Search PDB for entries with ligand similarity: