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Target
Substance-K receptor
Ligand
BDBM50002961
Substrate
n/a
Meas. Tech.
ChEMBL_448555 (CHEMBL897704)
Ki
126±n/a nM
Citation
 Sisto, A; Altamura, M; Cardinali, F; D'Andrea, P; Rossi, C; Fattori, D alpha,alpha-Cyclic aminoacids as useful scaffolds for the preparation of hNK(2) receptor antagonists. Bioorg Med Chem Lett 17:4841-4 (2007) [PubMed]  Article 
Target
Name:
Substance-K receptor
Synonyms:
NK2R_CAVPO | Neurokinin 2 receptor | Neurokinin NK2 | Substance-K receptor | TACR2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45106.00
Organism:
GUINEA PIG
Description:
Neurokinin NK2 TACR2 GUINEA PIG::Q64077
Residue:
402
Sequence:
MGACVIVTNTNISSGLESNTTGITAFSMPTWQLALWATAYLALVLVAVTGNATVTWIILAHQRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAIDRYMAIVHPFQPRLSAPSTKAVIGGIWLVALALAFPQCFYSTITEDEGATKCVVAWPEDSRDKSLLLYHLVVIVLIYLLPLTVMFVAYSIIGLTLWRRAVPRHQAHGANLRHLQAKKKFVKTMVLVVVTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNRRFRSGFRLAFRCCPWVTPTEEDKLELTHTPSFSLRVNRCHTKEILFMAGDTVPSEATNGQAGGPQDRESVELSSLPGCRAGPSILAKASS
  
Inhibitor
Name:
BDBM50002961
Synonyms:
CHEMBL237048
Type:
Small organic molecule
Emp. Form.:
C36H41N5O3S
Mol. Mass.:
623.807
SMILES:
CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(Cc3ccccc3C2)NC(=O)c2cc3ccccc3s2)CC1
Structure:
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