Reaction Details Report a problem with these data
Target
Calcium/calmodulin-dependent protein kinase type IV
Ligand
BDBM50001733
Substrate
n/a
Meas. Tech.
ChEMBL_1337316 (CHEMBL3241178)
IC50
>10000±n/a nM
Citation
 Mahmoud, KA; Krug, M; Wersig, T; Slynko, I; Schächtele, C; Totzke, F; Sippl, W; Hilgeroth, A Discovery of 4-anilinoa-carbolines as novel Brk inhibitors. Bioorg Med Chem Lett 24:1948-51 (2014) [PubMed]  Article 
Target
Name:
Calcium/calmodulin-dependent protein kinase type IV
Synonyms:
CAM kinase-GR | CAMK | CAMK-GR | CAMK4 | CAMKIV | CaM kinase IV | CaMK IV | Calcium/calmodulin-dependent protein kinase type IV | KCC4_HUMAN
Type:
PROTEIN
Mol. Mass.:
51919.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1459854
Residue:
473
Sequence:
MLKVTVPSCSASSCSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHGSIQESHKASRDPSPIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAELMKVQALEKVKGADINAEEAPKMVPKAVEDGIKVADLELEEGLAEEKLKTVEEAAAPREGQGSSAVGFEVPQQDVILPEY
  
Inhibitor
Name:
BDBM50001733
Synonyms:
CHEMBL3133821
Type:
Small organic molecule
Emp. Form.:
C17H13N3O
Mol. Mass.:
275.3046
SMILES:
Oc1cccc(Nc2ccnc3[nH]c4ccccc4c23)c1
Structure:
Search PDB for entries with ligand similarity: