Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50050467
Substrate
n/a
Meas. Tech.
ChEMBL_1335161 (CHEMBL3239710)
Ki
49±n/a nM
Citation
 Xiao, J; Free, RB; Barnaeva, E; Conroy, JL; Doyle, T; Miller, B; Bryant-Genevier, M; Taylor, MK; Hu, X; Dulcey, AE; Southall, N; Ferrer, M; Titus, S; Zheng, W; Sibley, DR; Marugan, JJ Discovery, optimization, and characterization of novel D2 dopamine receptor selective antagonists. J Med Chem 57:3450-63 (2014) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Human
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50050467
Synonyms:
1-((1H-indol-3-yl)methyl)-4-(4-chlorophenyl)piperidin-4-ol | 3-[4-(4-chlorophenyl)-4-hydroxypiperidinyl]methylindole | 4-(4-Chloro-phenyl)-1-(1H-indol-3-ylmethyl)-piperidin-4-ol | CHEMBL445102 | L-741626 | L741,626
Type:
Small organic molecule
Emp. Form.:
C20H21ClN2O
Mol. Mass.:
340.847
SMILES:
OC1(CCN(Cc2c[nH]c3ccccc23)CC1)c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: