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Target
Acetylcholinesterase
Ligand
BDBM50004269
Substrate
n/a
Meas. Tech.
ChEMBL_1335188 (CHEMBL3239772)
IC50
2320±n/a nM
Citation
 Belluti, F; De Simone, A; Tarozzi, A; Bartolini, M; Djemil, A; Bisi, A; Gobbi, S; Montanari, S; Cavalli, A; Andrisano, V; Bottegoni, G; Rampa, A Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease. Eur J Med Chem 78:157-66 (2014) [PubMed]  Article 
Target
Name:
Acetylcholinesterase
Synonyms:
ACES_HUMAN | ACHE | Acetylcholinesterase (AChE) | Acetylcholinesterase (human AChE)
Type:
Enzyme
Mol. Mass.:
67792.70
Organism:
Homo sapiens (Human)
Description:
P22303
Residue:
614
Sequence:
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQDRCSDL
  
Inhibitor
Name:
BDBM50004269
Synonyms:
CHEMBL3237527
Type:
Small organic molecule
Emp. Form.:
C21H24FNO3
Mol. Mass.:
357.4186
SMILES:
OCCC1CCN(Cc2ccc(cc2)C(=O)c2ccc(O)c(F)c2)CC1
Structure:
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