Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50004506
Substrate
n/a
Meas. Tech.
ChEMBL_1337403 (CHEMBL3241548)
Ki
>50000±n/a nM
Citation
 Moeker, J; Peat, TS; Bornaghi, LF; Vullo, D; Supuran, CT; Poulsen, SA Cyclic secondary sulfonamides: unusually good inhibitors of cancer-related carbonic anhydrase enzymes. J Med Chem 57:3522-31 (2014) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50004506
Synonyms:
6-Aminosaccharin | CHEMBL2016952 | Saccharin derivative, 5
Type:
Small organic molecule
Emp. Form.:
C7H6N2O3S
Mol. Mass.:
198.199
SMILES:
Nc1ccc2C(=O)NS(=O)(=O)c2c1
Structure:
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