Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50329607
Substrate
n/a
Meas. Tech.
ChEMBL_1337106 (CHEMBL3239991)
IC50
20±n/a nM
Citation
G-Dayanandan, N; Paulsen, JL; Viswanathan, K; Keshipeddy, S; Lombardo, MN; Zhou, W; Lamb, KM; Sochia, AE; Alverson, JB; Priestley, ND; Wright, DL; Anderson, AC Propargyl-linked antifolates are dual inhibitors of Candida albicans and Candida glabrata. J Med Chem 57:2643-56 (2014) [PubMed] Article
More Info.:
Target
Name:
Dihydrofolate reductase
Synonyms:
DFR1 | DYR_CANAX | Dihydrofolate Reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
22141.77
Organism:
Candida albicans
Description:
C. albicans DHFR was expressed in E. coli BL21, and purified to homogeneity.
Residue:
192
Sequence:
MSKPNVAIIVAALKPALGIGYKGKMPWRLRKEIRYFKDVTTRTTKPNTRNAVIMGRKTWESIPQKFRPLPDRLNIILSRSYENKIIDDNIIHASSIESSLNLVSDVERVFIIGGAEIYNELINNSLVSHLLITEIEHPSPESIEMDTFLKFPLESWTKQPKSELQKFVGDTVLEDDIKEGDFTYNYTLWTRK