Reaction Details Report a problem with these data
Target
Acetylcholinesterase
Ligand
BDBM50008924
Substrate
n/a
Meas. Tech.
ChEMBL_1337582 (CHEMBL3242491)
IC50
71500±n/a nM
Citation
 Ramli, RA; Lie, W; Pyne, SG Alkaloids from the roots of Stichoneuron caudatum and their acetylcholinesterase inhibitory activities. J Nat Prod 77:894-901 (2014) [PubMed]  Article 
Target
Name:
Acetylcholinesterase
Synonyms:
ACES_HUMAN | ACHE | Acetylcholinesterase (AChE) | Acetylcholinesterase (human AChE)
Type:
Enzyme
Mol. Mass.:
67792.70
Organism:
Homo sapiens (Human)
Description:
P22303
Residue:
614
Sequence:
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQDRCSDL
  
Inhibitor
Name:
BDBM50008924
Synonyms:
CHEMBL3237628
Type:
Small organic molecule
Emp. Form.:
C23H37NO5
Mol. Mass.:
407.5436
SMILES:
[H][C@]1(C[C@H](C)C(=O)O1)[C@]1([H])CC[C@]23O[C@@H](C[C@H](C)C(=O)OC)[C@H](CC)[C@@]2([H])CCCCN13 |r|
Structure:
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