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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50261184
Substrate
n/a
Meas. Tech.
ChEMBL_1335046 (CHEMBL3239477)
Ki
2.2±n/a nM
Citation
 Olberg, DE; Andressen, KW; Levy, FO; Klaveness, J; Haraldsen, I; Sutcliffe, JL Synthesis and in vitro evaluation of small-molecule [18F] labeled gonadotropin-releasing hormone (GnRH) receptor antagonists as potential PET imaging agents for GnRH receptor expression. Bioorg Med Chem Lett 24:1846-50 (2014) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_MOUSE | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37702.59
Organism:
Mus musculus
Description:
ChEMBL_108267
Residue:
327
Sequence:
MANNASLEQDPNHCSAINNSIPLIQGKLPTLTVSGKIRVTVTFFLFLLSTAFNASFLLKLQKWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITQPLAVQSNSKLEQSMISLAWILSIVFAGPQLYIFRMIYLADGSGPTVFSQCVTHCSFPQWWHQAFYNFFTFGCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFATSFVVCWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50261184
Synonyms:
5-((3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)methyl)-N-(2,4,6-trimethoxyphenyl)furan-2-carboxamide | CHEMBL494803
Type:
Small organic molecule
Emp. Form.:
C30H37NO5
Mol. Mass.:
491.6185
SMILES:
COc1cc(OC)c(NC(=O)c2ccc(Cc3cc4c(cc3C)C(C)(C)CCC4(C)C)o2)c(OC)c1
Structure:
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