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Target
Proteasome subunit beta type-7
Ligand
BDBM50015239
Substrate
n/a
Meas. Tech.
ChEMBL_1349633 (CHEMBL3266057)
IC50
340±n/a nM
Citation
 Zhang, J; Cao, J; Xu, L; Zhou, Y; Liu, T; Li, J; Hu, Y Design, synthesis and biological evaluation of novel tripeptidyl epoxyketone derivatives constructed fromß-amino acid as proteasome inhibitors. Bioorg Med Chem 22:2955-65 (2014) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-7
Synonyms:
Macropain chain Z | Multicatalytic endopeptidase complex chain Z | PSB7_HUMAN | PSMB7 | Proteasome subunit Z | Z
Type:
PROTEIN
Mol. Mass.:
29968.13
Organism:
Homo sapiens (Human)
Description:
ChEMBL_106197
Residue:
277
Sequence:
MAAVSVYAPPVGGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS
  
Inhibitor
Name:
BDBM50015239
Synonyms:
CHEMBL3262755
Type:
Small organic molecule
Emp. Form.:
C35H41N3O6
Mol. Mass.:
599.7165
SMILES:
COc1ccc(cc1)C(=O)NC(CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1)c1ccccc1 |r|
Structure:
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