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Target
Potassium voltage-gated channel subfamily A member 5
Ligand
BDBM50016335
Substrate
n/a
Meas. Tech.
ChEMBL_1348919 (CHEMBL3271550)
IC50
16110±n/a nM
Citation
 Guo, X; Ma, X; Yang, Q; Xu, J; Huang, L; Jia, J; Shan, J; Liu, L; Chen, W; Chu, H; Wei, J; Zhang, X; Sun, H; Tang, Y; You, Q Discovery of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors (part I). Eur J Med Chem 81:89-94 (2014) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 5
Synonyms:
HK2 | HPCN1 | KCNA5 | KCNA5_HUMAN | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.5
Type:
Enzyme
Mol. Mass.:
67222.47
Organism:
Homo sapiens (Human)
Description:
P22460
Residue:
613
Sequence:
MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSLYALCLDTSRETDL
  
Inhibitor
Name:
BDBM50016335
Synonyms:
CHEMBL3262821
Type:
Small organic molecule
Emp. Form.:
C21H27N3O2
Mol. Mass.:
353.458
SMILES:
Cc1ccc(NC(=O)CN2CCN(CCOc3ccccc3)CC2)cc1
Structure:
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