Reaction Details Report a problem with these data
Target
Delta-aminolevulinic acid dehydratase
Ligand
BDBM50017191
Substrate
n/a
Meas. Tech.
ChEMBL_1365622 (CHEMBL3297469)
IC50
371000±n/a nM
Citation
 Lentz, CS; Halls, VS; Hannam, JS; Strassel, S; Lawrence, SH; Jaffe, EK; Famulok, M; Hoerauf, A; Pfarr, KM wALADin benzimidazoles differentially modulate the function of porphobilinogen synthase orthologs. J Med Chem 57:2498-510 (2014) [PubMed]  Article 
Target
Name:
Delta-aminolevulinic acid dehydratase
Synonyms:
Dmel_CG10335 | EMBL:AAF49936.1 | EMBL:AAL48669.1 | FlyBase:FBgn0036271 | FlyBase:FBgn0036271} | Pbgs
Type:
PROTEIN
Mol. Mass.:
35938.25
Organism:
Drosophila melanogaster
Description:
ChEMBL_108389
Residue:
327
Sequence:
MERKLHSGMHHATLRQLQESGCEIAPHNLMYPVFIVSNDDDVQPIASMPGISRFGLNRLKEHLEPLVAKGLSSVLLFGVVDPDMKDEQASNADSAKNPVVLALPKLREWFPDLLIACDVCICPYSSHGHCGLLGETGLENGPSIKRIAEIAVAYAKAGAHIVAPSDMMDNRVKAIKQALIDAQMNSVSLLAYSAKFTSNFYGPFREAAQSAPKFGDRRCYQLPSGSRSLAMRAIQRDVAEGADMLMVKPGMPYLDILRSTKDSYPYHTLYVYQVSGEFAMLYHAAKAGAFDLKDAVLEAMKGFRRAGADCIITYYTPFLLDIIGKVK
  
Inhibitor
Name:
BDBM50017191
Synonyms:
CHEMBL3287367
Type:
Small organic molecule
Emp. Form.:
C16H14N2O2
Mol. Mass.:
266.2946
SMILES:
Cc1cccc(Cn2cnc3cc(ccc23)C(O)=O)c1
Structure:
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