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Target
Eukaryotic translation initiation factor 4E
Ligand
BDBM50018926
Substrate
n/a
Meas. Tech.
ChEMBL_1364496 (CHEMBL3295044)
IC50
16500±n/a nM
Citation
 Mahalingam, P; Takrouri, K; Chen, T; Sahoo, R; Papadopoulos, E; Chen, L; Wagner, G; Aktas, BH; Halperin, JA; Chorev, M Synthesis of rigidified eIF4E/eIF4G inhibitor-1 (4EGI-1) mimetic and their in vitro characterization as inhibitors of protein-protein interaction. J Med Chem 57:5094-111 (2014) [PubMed]  Article 
Target
Name:
Eukaryotic translation initiation factor 4E
Synonyms:
EIF4E | EIF4EL1 | EIF4F | Eukaryotic translation initation factor | Eukaryotic translation initiation factor 4E (eIF4E) | Eukaryotic translation initiation factor 4E/Eukaryotic translation initiation factor 4E-binding protein 1 | IF4E_HUMAN
Type:
Protein
Mol. Mass.:
25095.44
Organism:
Homo sapiens (Human)
Description:
P06730
Residue:
217
Sequence:
MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
  
Inhibitor
Name:
BDBM50018926
Synonyms:
CHEMBL3287128
Type:
Small organic molecule
Emp. Form.:
C21H18N4O7S
Mol. Mass.:
470.455
SMILES:
COc1ccc2-c3nc(N\N=C(/Cc4ccccc4[N+]([O-])=O)C(O)=O)sc3COc2c1OC
Structure:
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