Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50339489
Substrate
n/a
Meas. Tech.
ChEMBL_1361427 (CHEMBL3294051)
EC50
18±n/a nM
Citation
 Takano, R; Yoshida, M; Inoue, M; Honda, T; Nakashima, R; Matsumoto, K; Yano, T; Ogata, T; Watanabe, N; Toda, N Discovery of 3-aryl-3-ethoxypropanoic acids as orally active GPR40 agonists. Bioorg Med Chem Lett 24:2949-53 (2014) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1_RAT | Ffar1 | G-protein coupled receptor 40 | Gpr40
Type:
PROTEIN
Mol. Mass.:
31848.38
Organism:
Rattus norvegicus
Description:
ChEMBL_1511162
Residue:
300
Sequence:
MDLPPQLSFALYVSAFALGFPLNLLAIRGAVSHAKLRLTPSLVYTLHLACSDLLLAITLPLKAVEALASGVWPLPLPFCPVFALAHFAPLYAGGGFLAALSAGRYLGAAFPFGYQAIRRPCYSWGVCVAIWALVLCHLGLALGLEAPRGWVDNTTSSLGINIPVNGSPVCLEAWDPDSARPARLSFSILLFFLPLVITAFCYVGCLRALVHSGLSHKRKLRAAWVAGGALLTLLLCLGPYNASNVASFINPDLEGSWRKLGLITGAWSVVLNPLVTGYLGTGPGQGTICVTRTPRGTIQK
  
Inhibitor
Name:
BDBM50339489
Synonyms:
3-{4-[(2',6'-Dimethylbiphenyl-3-yl)methoxy]phenyl}propanoic Acid | CHEMBL1688486
Type:
Small organic molecule
Emp. Form.:
C24H24O3
Mol. Mass.:
360.4456
SMILES:
Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(O)=O)cc2)c1
Structure:
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