Reaction Details Report a problem with these data
Target
G-protein coupled bile acid receptor 1
Ligand
BDBM50019498
Substrate
n/a
Meas. Tech.
ChEMBL_1365356 (CHEMBL3292680)
EC50
17±n/a nM
Citation
 Zou, Q; Duan, H; Ning, M; Liu, J; Feng, Y; Zhang, L; Zhu, J; Leng, Y; Shen, J 4-Benzofuranyloxynicotinamide derivatives are novel potent and orally available TGR5 agonists. Eur J Med Chem 82:1-15 (2014) [PubMed]  Article 
Target
Name:
G-protein coupled bile acid receptor 1
Synonyms:
BG37 | GPBAR1 | GPBAR_HUMAN | M-BAR | TGR5 | hBG37 | hGPCR19
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
35260.02
Organism:
Homo sapiens (Human)
Description:
CHO cells transiently transfected with hTGR5.
Residue:
330
Sequence:
MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQPPGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGAAAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQGLWGRASRDSPGPSIAYHPSSQSSVDLDLN
  
Inhibitor
Name:
BDBM50019498
Synonyms:
CHEMBL3290700
Type:
Small organic molecule
Emp. Form.:
C27H23N3O2
Mol. Mass.:
421.4904
SMILES:
O=C(N1CCN(C2CC2)c2ccccc12)c1cnccc1Oc1cccc2ccccc12
Structure:
Search PDB for entries with ligand similarity: