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Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50090524
Substrate
n/a
Meas. Tech.
ChEMBL_1361508 (CHEMBL3294612)
Ki
12±n/a nM
Citation
 Krogsgaard-Larsen, N; Jensen, AA; Schrøder, TJ; Christoffersen, CT; Kehler, J Novel aza-analogous ergoline derived scaffolds as potent serotonin 5-HT6 and dopamine D2 receptor ligands. J Med Chem 57:5823-8 (2014) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM50090524
Synonyms:
4-Amino-N-(2,6-bis-methylamino-pyridin-4-yl)-benzenesulfonamide | 4-Amino-N-(2,6-diamino-pyridin-4-yl)-benzenesulfonamide | 4-Amino-N-(2-methylamino-pyridin-4-yl)-benzenesulfonamide | CHEMBL46071 | N-(2,6-bis(methylamino)pyridin-4-yl)-4-aminobenzenesulfonamide | Ro-63-0563
Type:
Small organic molecule
Emp. Form.:
C13H17N5O2S
Mol. Mass.:
307.371
SMILES:
CNc1cc(NS(=O)(=O)c2ccc(N)cc2)cc(NC)n1
Structure:
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