Reaction Details Report a problem with these data
Target
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Ligand
BDBM50019796
Substrate
n/a
Meas. Tech.
ChEMBL_1361547 (CHEMBL3294871)
Kd
328±n/a nM
Citation
 Zimmermann, G; Schultz-Fademrecht, C; Küchler, P; Murarka, S; Ismail, S; Triola, G; Nussbaumer, P; Wittinghofer, A; Waldmann, H Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEd prenyl binding site. J Med Chem 57:5435-48 (2014) [PubMed]  Article 
Target
Name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Synonyms:
3',5'-cyclic phosphodiesterase | GMP-PDE delta | PDE6D | PDE6D_HUMAN | PDED | Protein p17 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Type:
PROTEIN
Mol. Mass.:
17418.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105761
Residue:
150
Sequence:
MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVSRELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSRVRLFYV
  
Inhibitor
Name:
BDBM50019796
Synonyms:
CHEMBL3286888
Type:
Small organic molecule
Emp. Form.:
C57H66N8O7S
Mol. Mass.:
1007.248
SMILES:
[H][C@]12CS[C@@H](CCCCC(=O)NCCCOCCOCCOCCCNC(=O)CC(COc3ccc(cc3)-c3nc4ccccc4n3Cc3ccccc3)n3c(nc4ccccc34)-c3ccccc3)[C@@]1([H])NC(=O)N2 |r|
Structure:
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