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Target
Intermediate conductance calcium-activated potassium channel protein 4
Ligand
BDBM50019903
Substrate
n/a
Meas. Tech.
ChEMBL_1361891 (CHEMBL3293066)
IC50
48±n/a nM
Citation
 Blass, B Fused Thiazin-3-ones as KCa3.1 Inhibitors. ACS Med Chem Lett 5:460-1 (2014) [PubMed]  Article 
Target
Name:
Intermediate conductance calcium-activated potassium channel protein 4
Synonyms:
IK1 | IKCA1 | KCA4 | KCNN4 | KCNN4_HUMAN | Putative Gardos channel | SK4
Type:
PROTEIN
Mol. Mass.:
47723.22
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1361891
Residue:
427
Sequence:
MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFLVKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPAPVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLPEPSQQSK
  
Inhibitor
Name:
BDBM50019903
Synonyms:
CHEMBL3287208 | US9533999, i-40
Type:
Small organic molecule
Emp. Form.:
C14H9F4NO4S2
Mol. Mass.:
395.349
SMILES:
Fc1ccc(CN2c3ccsc3S(=O)(=O)CC2=O)cc1OC(F)(F)F
Structure:
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