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Target
Diacylglycerol O-acyltransferase 1
Ligand
BDBM50020063
Substrate
n/a
Meas. Tech.
ChEMBL_1363771 (CHEMBL3294188)
IC50
300±n/a nM
Citation
 Zhou, G; Zorn, N; Ting, P; Aslanian, R; Lin, M; Cook, J; Lachowicz, J; Lin, A; Smith, M; Hwa, J; van Heek, M; Walker, S Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors. ACS Med Chem Lett 5:544-9 (2014) [PubMed]  Article 
Target
Name:
Diacylglycerol O-acyltransferase 1
Synonyms:
ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:
Protein
Mol. Mass.:
55297.82
Organism:
Homo sapiens (Human)
Description:
O75907
Residue:
488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA
  
Inhibitor
Name:
BDBM50020063
Synonyms:
CHEMBL3287886
Type:
Small organic molecule
Emp. Form.:
C29H31N3O4
Mol. Mass.:
485.5741
SMILES:
ONC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc2N(CCOc2c1)C(=O)Nc1ccccc1 |r,wU:8.11,wD:5.4,(23.03,-4.59,;23.07,-6.13,;21.75,-6.93,;20.4,-6.19,;21.79,-8.47,;20.47,-9.27,;19.12,-8.52,;17.81,-9.32,;17.85,-10.86,;19.2,-11.6,;20.51,-10.8,;16.53,-11.66,;15.18,-10.92,;13.87,-11.72,;13.91,-13.26,;15.26,-14,;16.57,-13.2,;12.59,-14.06,;12.63,-15.6,;11.32,-16.4,;9.96,-15.66,;8.65,-16.46,;7.3,-15.72,;7.26,-14.18,;8.58,-13.38,;9.93,-14.12,;11.24,-13.32,;8.69,-18,;10.03,-18.73,;7.37,-18.8,;7.41,-20.34,;6.09,-21.13,;6.13,-22.67,;7.48,-23.41,;8.8,-22.6,;8.76,-21.07,)|
Structure:
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