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Target
Chloroquine resistance transporter
Ligand
BDBM35938
Substrate
n/a
Meas. Tech.
ChEMBL_1364181 (CHEMBL3292896)
IC50
54000±n/a nM
Citation
 Deane, KJ; Summers, RL; Lehane, AM; Martin, RE; Barrow, RA Chlorpheniramine Analogues Reverse Chloroquine Resistance in Plasmodium falciparum by Inhibiting PfCRT. ACS Med Chem Lett 5:576-81 (2014) [PubMed]  Article 
Target
Name:
Chloroquine resistance transporter
Synonyms:
CRT | CRT_PLAFA | PfCRT
Type:
PROTEIN
Mol. Mass.:
48687.29
Organism:
Plasmodium falciparum
Description:
ChEMBL_1364181
Residue:
424
Sequence:
MKFASKKNNQKNSSKNDERYRELDNLVQEGNGSRLGGGSCLGKCAHVFKLIFKEIKDNIFIYILSIIYLSVCVMNKIFAKRTLNKIGNYSFVTSETHNFICMIMFFIVYSLFGNKKGNSKERHRSFNLQFFAISMLDACSVILAFIGLTRTTGNIQSFVLQLSIPINMFFCFLILRYRYHLYNYLGAVIIVVTIALVEMKLSFETQEENSIIFNLVLISALIPVCFSNMTREIVFKKYKIDILRLNAMVSFFQLFTSCLILPVYTLPFLKQLHLPYNEIWTNIKNGFACLFLGRNTVVENCGLGMAKLCDDCDGAWKTFALFSFFNICDNLITSYIIDKFSTMTYTIVSCIQGPAIAIAYYFKFLAGDVVREPRLLDFVTLFGYLFGSIIYRVGNIILERKKMRNEENEDSEGELTNVDSIITQ
  
Inhibitor
Name:
BDBM35938
Synonyms:
1-(p-chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpropylamine | 1-(p-chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane | 3-(p-chlorophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine | 5-HT,N-ACETYL | CHEMBL505 | CHLORPHENIRAMINE | CHLORPHENIRAMINE MALEATE | Polaramin | Polaramine | Polaronil | [3H]Chlorphenamine | [3H]Chlorpheniramine | chlorophenylpyridamine | chlorphenamine | clorfeniramina | d-Chlorpheniramine | gamma-(4-chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine | gamma-(4-chlorophenyl)-gamma-(2-pyridyl)propyldimethylamine
Type:
radiolabeled ligand
Emp. Form.:
C16H19ClN2
Mol. Mass.:
274.788
SMILES:
CN(C)CCC(c1ccc(Cl)cc1)c1ccccn1
Structure:
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