Reaction Details Report a problem with these data
Target
Somatostatin receptor type 3
Ligand
BDBM50400517
Substrate
n/a
Meas. Tech.
ChEMBL_1365888 (CHEMBL3296546)
IC50
0.460000±n/a nM
Citation
 Li, D; Wu, Z; Yu, Y; Ball, RG; Guo, L; Sherer, E; He, S; Hong, Q; Lai, Z; Qi, H; Truong, Q; Yang, DX; Chicchi, GG; Tsao, KL; Trusca, D; Trujillo, M; Pachanski, M; Eiermann, GJ; Howard, AD; Zhou, YP; Zhang, BB; Nargund, RP; Hagmann, WK Diamine Derivatives as Novel Small-Molecule, Potent, and Subtype-Selective Somatostatin SST3 Receptor Agonists. ACS Med Chem Lett 5:690-5 (2014) [PubMed]  Article 
Target
Name:
Somatostatin receptor type 3
Synonyms:
SOMATOSTATIN SST3 | SS3R | SSR-28 | SSR3_MOUSE | Smstr3 | Somatostatin receptor | Somatostatin receptor 3 | Somatostatin receptor type 3 | Sstr3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47225.49
Organism:
MOUSE
Description:
SOMATOSTATIN SST3 SSTR3 MOUSE::P30935
Residue:
428
Sequence:
MATVTYPSSEPTTLDPGNASSTWPLDTTLGNTSAGASLTGLAVSGILISLVYLVVCVVGLLGNSLVIYVVLRHTSSPSVTSVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRTAFIIYTAALGFFGPLLVICLCYLLIVVKVRSTTRRVRAPSCQWVQAPACQRRRRSERRVTRMVVAVVALFVLCWMPFYLLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRILLRPSRRIRSQEPGSGPPEKTEEEEDEEEEERREEEERRMQRGQEMNGRLSQIAQAGTSGQQPRPCTGTAKEQQLLPQEATAGDKASTLSHL
  
Inhibitor
Name:
BDBM50400517
Synonyms:
CHEMBL2204935
Type:
Small organic molecule
Emp. Form.:
C27H23FN8O
Mol. Mass.:
494.5229
SMILES:
Cc1nc(no1)[C@@]1(N[C@H](Cc2c1[nH]c1ccccc21)c1nc(c[nH]1)-c1ccc(F)cc1)c1cnn(C)c1 |r|
Structure:
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