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Target
Sodium-dependent dopamine transporter
Ligand
BDBM30701
Substrate
n/a
Meas. Tech.
ChEMBL_1442871 (CHEMBL3377149)
EC50
321±n/a nM
Citation
 Blough, BE; Landavazo, A; Partilla, JS; Decker, AM; Page, KM; Baumann, MH; Rothman, RB Alpha-ethyltryptamines as dual dopamine-serotonin releasers. Bioorg Med Chem Lett 24:4754-8 (2014) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT)
Type:
Multi-pass membrane protein
Mol. Mass.:
68749.45
Organism:
Rattus norvegicus (rat)
Description:
P23977
Residue:
619
Sequence:
MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDHQLVDRGEVRQFTLRHWLLL
  
Inhibitor
Name:
BDBM30701
Synonyms:
2-(1H-indol-3-yl)-N-methyl-ethanamine | 2-(1H-indol-3-yl)-N-methylethanamine | 2-(1H-indol-3-yl)ethyl-methyl-amine | MLS000069493 | N-OMEGA-METHYLTRYPTAMINE | N-methyltryptamine | SMR000059062 | cid_6088
Type:
Small organic molecule
Emp. Form.:
C11H14N2
Mol. Mass.:
174.2423
SMILES:
CNCCc1c[nH]c2ccccc12
Structure:
Search PDB for entries with ligand similarity: