Reaction Details Report a problem with these data
Target
Melatonin receptor type 1B
Ligand
BDBM50027383
Substrate
n/a
Meas. Tech.
ChEMBL_1442966 (CHEMBL3378364)
Ki
>10000±n/a nM
Citation
 Párraga, J; Moreno, L; Diaz, A; El Aouad, N; Galán, A; Sanz, MJ; Caignard, DH; Figadčre, B; Cabedo, N; Cortes, D Efficient synthesis of hexahydroindenopyridines and their potential as melatoninergic ligands. Eur J Med Chem 86:700-9 (2014) [PubMed]  Article 
Target
Name:
Melatonin receptor type 1B
Synonyms:
MTNR1B | MTR1B_HUMAN | Mel-1B-R | Mel1b melatonin receptor | Melatonin 1B | Melatonin receptor | Melatonin receptor type 1B | Melatonin receptor type 2 (MT2)
Type:
Enzyme
Mol. Mass.:
40203.54
Organism:
Homo sapiens (Human)
Description:
P49286
Residue:
362
Sequence:
MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL
  
Inhibitor
Name:
BDBM50027383
Synonyms:
CHEMBL3329371
Type:
Small organic molecule
Emp. Form.:
C22H33N3O2S
Mol. Mass.:
403.581
SMILES:
COc1cc2CC3CCCN(C3c2cc1OC)C(=S)NCCN1CCCCC1
Structure:
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