Reaction Details
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Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50027489
Substrate
n/a
Meas. Tech.
ChEMBL_1442973 (CHEMBL3378918)
EC50
7300±n/a nM
Citation
Balsera, B; Mulet, J; Fernández-Carvajal, A; de la Torre-Martínez, R; Ferrer-Montiel, A; Hernández-Jiménez, JG; Estévez-Herrera, J; Borges, R; Freitas, AE; López, MG; García-López, MT; González-Muńiz, R; Pérez de Vega, MJ; Valor, LM; Svobodová, L; Sala, S; Sala, F; Criado, M Chalcones as positive allosteric modulators ofa7 nicotinic acetylcholine receptors: a new target for a privileged structure. Eur J Med Chem 86:724-39 (2014) [PubMed] Article More Info.:
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
Inhibitor
Name:
BDBM50027489
Synonyms:
CHEMBL3335597
Type:
Small organic molecule
Emp. Form.:
C19H20O5
Mol. Mass.:
328.3591
SMILES:
COc1ccc(\C=C\C(=O)c2ccc(O)cc2C)c(OC)c1OC
Structure:
