Reaction Details Report a problem with these data
Target
G-protein coupled receptor 39
Ligand
BDBM50030775
Substrate
n/a
Meas. Tech.
ChEMBL_1438504 (CHEMBL3385494)
EC50
8.0±n/a nM
Citation
 Peukert, S; Hughes, R; Nunez, J; He, G; Yan, Z; Jain, R; Llamas, L; Luchansky, S; Carlson, A; Liang, G; Kunjathoor, V; Pietropaolo, M; Shapiro, J; Castellana, A; Wu, X; Bose, A Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists. ACS Med Chem Lett 5:1114-8 (2014) [PubMed]  Article 
Target
Name:
G-protein coupled receptor 39
Synonyms:
G-protein coupled receptor 39 | GPR39_MOUSE | Gpr39
Type:
PROTEIN
Mol. Mass.:
51615.79
Organism:
Mus musculus
Description:
ChEMBL_109498
Residue:
456
Sequence:
MASSSGSNHICSRVIDHSHVPEFEVATWIKITLILVYLIIFVVGILGNSVTIRVTQVLQKKGYLQKEVTDHMVSLACSDILVFLIGMPMEFYSIIWNPLTTPSYALSCKLHTFLFETCSYATLLHVLTLSFERYIAICHPFKYKAVSGPRQVKLLIGFVWVTSALVALPLLFAMGIEYPLVNVPTHKGLNCNLSRTRHHDEPGNSNMSICTNLSNRWEVFQSSIFGAFAVYLVVLASVAFMCWNMMKVLMKSKQGTLAGTGPQLQLRKSESEESRTARRQTIIFLRLIVVTLAVCWMPNQIRRIMAAAKPKHDWTRTYFRAYMILLPFSDTFFYLSSVVNPLLYNVSSQQFRKVFWQVLCCRLTLQHANQEKRQRARFISTKDSTSSARSPLIFLASRRSNSSSRRTNKVFLSTFQTEAKPGEAKPQPLSPESPQTGSETKPAGSTTENSLQEQEV
  
Inhibitor
Name:
BDBM50030775
Synonyms:
CHEMBL3342378
Type:
Small organic molecule
Emp. Form.:
C19H20N6O
Mol. Mass.:
348.4017
SMILES:
CNC(=O)c1ccc(CNc2cc(nc(NC)n2)-c2ccccn2)cc1
Structure:
Search PDB for entries with ligand similarity: