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Target
RCG37580
Ligand
BDBM50030774
Substrate
n/a
Meas. Tech.
ChEMBL_1438505 (CHEMBL3385495)
EC50
0.600000±n/a nM
Citation
 Peukert, S; Hughes, R; Nunez, J; He, G; Yan, Z; Jain, R; Llamas, L; Luchansky, S; Carlson, A; Liang, G; Kunjathoor, V; Pietropaolo, M; Shapiro, J; Castellana, A; Wu, X; Bose, A Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists. ACS Med Chem Lett 5:1114-8 (2014) [PubMed]  Article 
Target
Name:
RCG37580
Synonyms:
Ensembl:ENSRNOP00000036196 | G protein-coupled receptor 39-1b | Gpr39 | Protein Gpr39 | RCG37580
Type:
PROTEIN
Mol. Mass.:
33217.74
Organism:
Rattus norvegicus
Description:
ChEMBL_107978
Residue:
298
Sequence:
MASSSGSSNICSRVIDHSHVPEFEVATWIKITLTLVYLIVFVVGILGNSVTIRVTQVLQKKGYLQKEVTDHMISLACSDILVFLIGMPMEFYSIIWNPLTTPSYALSCKLHTFLFETCSYATLLHVLTLSFERYIAICHPFRYKDVSGPCQVKLLIGFVWVTSALVALPLLFAMGIEYPLANVPTHKGLNCNLSRTRHHDHPGDSNMSICTNLSSRWEVFQSSIFGAFAVYLVVLVSVAFMCWNMMKVLMKSKRGTLAGTGPQLQLRKSESEESRTARRQTIIFLSESGSRGILGPLA
  
Inhibitor
Name:
BDBM50030774
Synonyms:
CHEMBL3342379
Type:
Small organic molecule
Emp. Form.:
C19H19FN6O
Mol. Mass.:
366.3922
SMILES:
CNc1nc(NCc2ccc(NC(C)=O)cc2F)cc(n1)-c1ccccn1
Structure:
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