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Target
Malate dehydrogenase, mitochondrial
Ligand
BDBM50400094
Substrate
n/a
Meas. Tech.
ChEMBL_1440896 (CHEMBL3374599)
Ki
1900±n/a nM
Citation
 Naik, R; Won, M; Ban, HS; Bhattarai, D; Xu, X; Eo, Y; Hong, YS; Singh, S; Choi, Y; Ahn, HC; Lee, K Synthesis and structure-activity relationship study of chemical probes as hypoxia induced factor-1a/malate dehydrogenase 2 inhibitors. J Med Chem 57:9522-38 (2014) [PubMed]  Article 
Target
Name:
Malate dehydrogenase, mitochondrial
Synonyms:
MDH2 | MDHM_HUMAN
Type:
PROTEIN
Mol. Mass.:
35512.45
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1456625
Residue:
338
Sequence:
MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK
  
Inhibitor
Name:
BDBM50400094
Synonyms:
CHEMBL427092
Type:
Small organic molecule
Emp. Form.:
C26H29NO5
Mol. Mass.:
435.5122
SMILES:
COC(=O)c1ccc(O)c(NC(=O)COc2ccc(cc2)C23CC4CC(CC(C4)C2)C3)c1 |TLB:18:21:24.23.28:26,THB:22:23:26:30.21.29,22:21:24.23.28:26,29:21:24:28.27.26,29:27:24:30.22.21|
Structure:
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