Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Carbonic anhydrase 12
Ligand
BDBM50031588
Substrate
n/a
Meas. Tech.
ChEMBL_1441644 (CHEMBL3377090)
Kd
6.7±n/a nM
Citation
Dudutiene, V; Matuliene, J; Smirnov, A; Timm, DD; Zubriene, A; Baranauskiene, L; Morkunaite, V; Smirnoviene, J; Michailoviene, V; Juozapaitiene, V; Mickeviciute, A; Kazokaite, J; Bakšyte, S; Kasiliauskaite, A; Jachno, J; Revuckiene, J; Kišonaite, M; Pilipuityte, V; Ivanauskaite, E; Milinaviciute, G; Smirnovas, V; Petrikaite, V; Kairys, V; Petrauskas, V; Norvaišas, P; Linge, D; Gibieža, P; Capkauskaite, E; Zakšauskas, A; Kazlauskas, E; Manakova, E; Gražulis, S; Ladbury, JE; Matulis, D Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX. J Med Chem 57:9435-46 (2014) [PubMed] Article More Info.:
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | Carbonate dehydratase XII | Tumor antigen HOM-RCC-3.1.3 | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII (CAXII) | Carbonic anhydrase XII (CA XII) | CAH12_HUMAN | CA12 | Carbonic anhydrase | Carbonic anhydrase XII
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Human
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
Inhibitor
Name:
BDBM50031588
Synonyms:
CHEMBL3359181
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
