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Target
Myeloblastin
Ligand
BDBM50031630
Substrate
n/a
Meas. Tech.
ChEMBL_1442536 (CHEMBL3371660)
IC50
530±n/a nM
Citation
 Budnjo, A; Narawane, S; Grauffel, C; Schillinger, AS; Fossen, T; Reuter, N; Haug, BE Reversible ketomethylene-based inhibitors of human neutrophil proteinase 3. J Med Chem 57:9396-408 (2014) [PubMed]  Article 
Target
Name:
Myeloblastin
Synonyms:
Leukocyte proteinase 3 | MBN | PRTN3 | PRTN3_HUMAN
Type:
PROTEIN
Mol. Mass.:
27816.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1463425
Residue:
256
Sequence:
MAHRPPSPALASVLLALLLSGAARAAEIVGGHEAQPHSRPYMASLQMRGNPGSHFCGGTLIHPSFVLTAAHCLRDIPQRLVNVVLGAHNVRTQEPTQQHFSVAQVFLNNYDAENKLNDVLLIQLSSPANLSASVATVQLPQQDQPVPHGTQCLAMGWGRVGAHDPPAQVLQELNVTVVTFFCRPHNICTFVPRRKAGICFGDSGGPLICDGIIQGIDSFVIWGCATRLFPDFFTRVALYVDWIRSTLRRVEAKGRP
  
Inhibitor
Name:
BDBM50031630
Synonyms:
CHEMBL3359765
Type:
Small organic molecule
Emp. Form.:
C54H71N13O19
Mol. Mass.:
1206.2172
SMILES:
CCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1N)C(C)C)C(=O)C[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCCNc1ccc(cc1[N+]([O-])=O)[N+]([O-])=O |r|
Structure:
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