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Target
Histone deacetylase 2
Ligand
BDBM50036880
Substrate
n/a
Meas. Tech.
ChEMBL_1434457 (CHEMBL3388274)
IC50
100500±n/a nM
Citation
 Zwick, V; Chatzivasileiou, AO; Deschamps, N; Roussaki, M; Simões-Pires, CA; Nurisso, A; Denis, I; Blanquart, C; Martinet, N; Carrupt, PA; Detsi, A; Cuendet, M Aurones as histone deacetylase inhibitors: identification of key features. Bioorg Med Chem Lett 24:5497-501 (2015) [PubMed]  Article 
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM50036880
Synonyms:
CHEMBL199974
Type:
Small organic molecule
Emp. Form.:
C15H10O3
Mol. Mass.:
238.2381
SMILES:
Oc1ccc(\C=C2/Oc3ccccc3C2=O)cc1
Structure:
Search PDB for entries with ligand similarity: