Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50039666
Substrate
n/a
Meas. Tech.
ChEMBL_1445413 (CHEMBL3379646)
EC50
54±n/a nM
Citation
 Guidetti, R; Astles, PC; Sanderson, AJ; Hollinshead, SP; Johnson, MP; Chambers, MG The SAR development of substituted purine derivatives as selective CB2 agonists for the treatment of chronic pain. Bioorg Med Chem Lett 24:5572-5 (2014) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50039666
Synonyms:
CHEMBL3139150
Type:
Small organic molecule
Emp. Form.:
C21H26ClN7O
Mol. Mass.:
427.93
SMILES:
CN1CCN(CC1)c1nc(C)nc2n(CCNC(C)=O)c(nc12)-c1ccccc1Cl
Structure:
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