Reaction Details Report a problem with these data
Target
Reverse transcriptase
Ligand
BDBM50040230
Substrate
n/a
Meas. Tech.
ChEMBL_1443743 (CHEMBL3371716)
IC50
680±n/a nM
Citation
 Cao, Y; Zhang, Y; Wu, S; Yang, Q; Sun, X; Zhao, J; Pei, F; Guo, Y; Tian, C; Zhang, Z; Wang, H; Ma, L; Liu, J; Wang, X Synthesis and biological evaluation of pyridinone analogues as novel potent HIV-1 NNRTIs. Bioorg Med Chem 23:149-59 (2014) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50040230
Synonyms:
CHEMBL3359507
Type:
Small organic molecule
Emp. Form.:
C20H25BrN2O
Mol. Mass.:
389.329
SMILES:
CC1CCCCC1Nc1cc(CCc2ccccc2)[nH]c(=O)c1Br
Structure:
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