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Target
Caspase-7
Ligand
BDBM50040275
Substrate
n/a
Meas. Tech.
ChEMBL_1443756 (CHEMBL3371729)
IC50
182±n/a nM
Citation
 Li, Z; Pan, Y; Zhong, W; Zhu, Y; Zhao, Y; Li, L; Liu, W; Zhou, H; Yang, C Synthesis and evaluation of N-acyl-substituted 1,2-benzisothiazol-3-one derivatives as caspase-3 inhibitors. Bioorg Med Chem 22:6735-45 (2015) [PubMed]  Article 
Target
Name:
Caspase-7
Synonyms:
Apoptotic protease Mch-3 | CASP-7 | CASP7 | CASP7_HUMAN | CMH-1 | Caspase | MCH3 | caspase 7, apoptosis-related cysteine peptidase
Type:
Enzyme
Mol. Mass.:
34273.91
Organism:
Homo sapiens (Human)
Description:
P55210
Residue:
303
Sequence:
MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELYFSQ
  
Inhibitor
Name:
BDBM50040275
Synonyms:
CHEMBL3360031
Type:
Small organic molecule
Emp. Form.:
C16H13NO2S
Mol. Mass.:
283.345
SMILES:
Cc1ccc(CC(=O)n2sc3ccccc3c2=O)cc1
Structure:
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