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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50041551
Substrate
n/a
Meas. Tech.
ChEMBL_1445775 (CHEMBL3375484)
IC50
107±n/a nM
Citation
 Abdel-Magid, AF GnRH antagonists: the promise of treating sex-hormone-related diseases. ACS Med Chem Lett 5:1268-9 (2014) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50041551
Synonyms:
CHEMBL3358414
Type:
Small organic molecule
Emp. Form.:
C30H26F4N4O5S2
Mol. Mass.:
662.675
SMILES:
Fc1cc(cnc1CNC(=O)c1ccc2N(C(C3CC3)C3(CCS(=O)(=O)CC3)c2c1)S(=O)(=O)c1cccc(c1)C#N)C(F)(F)F
Structure:
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