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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50041553
Substrate
n/a
Meas. Tech.
ChEMBL_1445775 (CHEMBL3375484)
IC50
9350±n/a nM
Citation
 Abdel-Magid, AF GnRH antagonists: the promise of treating sex-hormone-related diseases. ACS Med Chem Lett 5:1268-9 (2014) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50041553
Synonyms:
CHEMBL3358416
Type:
Small organic molecule
Emp. Form.:
C29H26Cl2F3N3O5S2
Mol. Mass.:
688.565
SMILES:
FC(F)(F)c1cnc(CNC(=O)c2ccc3N(C(C4CC4)C4(CCS(=O)(=O)CC4)c3c2)S(=O)(=O)c2ccc(Cl)cc2)c(Cl)c1
Structure:
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