Reaction Details Report a problem with these data
Target
Transcription factor Jun
Ligand
BDBM50279699
Substrate
n/a
Meas. Tech.
ChEMBL_1458002 (CHEMBL3367176)
IC50
5500±n/a nM
Citation
 Ye, N; Ding, Y; Wild, C; Shen, Q; Zhou, J Small molecule inhibitors targeting activator protein 1 (AP-1). J Med Chem 57:6930-48 (2014) [PubMed]  Article 
Target
Name:
Transcription factor Jun
Synonyms:
AP1 | Activator protein 1 | JUN | JUN_HUMAN | Proto-oncogene c-JUN | Transcription factor AP-1 | Transcription factor AP1 | V-jun avian sarcoma virus 17 oncogene homolog | p39
Type:
n/a
Mol. Mass.:
35683.24
Organism:
Homo sapiens (Human)
Description:
P05412
Residue:
331
Sequence:
MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDLLTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGALSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
  
Inhibitor
Name:
BDBM50279699
Synonyms:
2-(4-Methyl-2-phenylamino-thiazol-5-yl)-3-o-tolyl-3H-quinazolin-4-one | CHEMBL474718
Type:
Small organic molecule
Emp. Form.:
C25H20N4OS
Mol. Mass.:
424.517
SMILES:
Cc1nc(Nc2ccccc2)sc1-c1nc2ccccc2c(=O)n1-c1ccccc1C |(-4.16,-12.94,;-3.02,-11.9,;-1.51,-12.22,;-.75,-10.89,;.79,-10.88,;1.56,-12.21,;.79,-13.55,;1.57,-14.87,;3.11,-14.87,;3.87,-13.52,;3.09,-12.2,;-1.78,-9.74,;-3.18,-10.37,;-4.51,-9.6,;-5.86,-10.38,;-7.2,-9.61,;-8.54,-10.38,;-9.87,-9.61,;-9.87,-8.06,;-8.54,-7.29,;-7.21,-8.06,;-5.87,-7.27,;-5.88,-5.73,;-4.52,-8.05,;-3.19,-7.27,;-1.86,-8.04,;-.52,-7.27,;-.53,-5.73,;-1.87,-4.96,;-3.2,-5.74,;-4.54,-4.98,)|
Structure:
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