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Target
Neuropilin-1
Ligand
BDBM50047413
Substrate
n/a
Meas. Tech.
ChEMBL_1448512 (CHEMBL3379264)
Ki
7300±n/a nM
Citation
 Starzec, A; Miteva, MA; Ladam, P; Villoutreix, BO; Perret, GY Discovery of novel inhibitors of vascular endothelial growth factor-A-Neuropilin-1 interaction by structure-based virtual screening. Bioorg Med Chem 22:4042-8 (2014) [PubMed]  Article 
Target
Name:
Neuropilin-1
Synonyms:
CD_antigen=CD304 | NRP1_RAT | Neuropilin-1 | Nrp1 | Vascular endothelial cell growth factor 165 receptor
Type:
PROTEIN
Mol. Mass.:
103073.15
Organism:
Rattus norvegicus
Description:
ChEMBL_109427
Residue:
922
Sequence:
MERGLPLLCATLALALALAGAFRSDKCGGTIKIENPGYLTSPGYPHSYHPSEKCEWLIQAPEPYQRIMINFNPHFDLEDRDCKYDYVEVIDGENEGGRLWGKFCGKIAPSPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTAPTGVIKSPGFPEKYPNSLECTYIIFAPKMSEIILEFESFDLEQDSNPPGGVFCRYDRLEIWDGFPEVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSISEDFKCMEALGMESGEIHSDQITASSQYGTNWSVERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYRVDISSNGEDWITLKEGNKAIIFQGNTNPTDVVFGVFPKPLITRFVRIKPASWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITASNQGDRNWMPENIRLVTSRTGWALPPSPHPYINEWLQVDLGDEKIVRGVIIQGGKHRENKVFMRKFKIAYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRAFTPLSTRFIRIYPERATHSGLGLRMELLGCEVEVPTAGPTTPNGNPVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTIIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDSHAQLRWRVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQSSAHCMTFWYHMSGSHVGTLRVKLHYQKPEEYDQLVWMVVGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHIPQEDCAKPTDLDKKNTEIKIDETGSTPGYEEGKGDKNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNPQSNYSEA
  
Inhibitor
Name:
BDBM50047413
Synonyms:
CHEMBL1624864
Type:
Small organic molecule
Emp. Form.:
C17H18Cl3NO3
Mol. Mass.:
390.689
SMILES:
COc1cc(CNCCO)cc(Cl)c1OCc1ccc(Cl)cc1Cl
Structure:
Search PDB for entries with ligand similarity: