Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50047916
Substrate
n/a
Meas. Tech.
ChEMBL_1451986 (CHEMBL3363688)
Ki
11±n/a nM
Citation
 Tosh, DK; Paoletta, S; Chen, Z; Moss, SM; Gao, ZG; Salvemini, D; Jacobson, KA Extended N(6) substitution of rigid C2-arylethynyl nucleosides for exploring the role of extracellular loops in ligand recognition at the A3 adenosine receptor. Bioorg Med Chem Lett 24:3302-6 (2014) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50047916
Synonyms:
CHEMBL3311283
Type:
Small organic molecule
Emp. Form.:
C27H24N6O6
Mol. Mass.:
528.5161
SMILES:
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NC3CC3c3cccc(c3)[N+]([O-])=O)nc(nc12)C#Cc1ccccc1 |r|
Structure:
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