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Target
Thioredoxin glutathione reductase
Ligand
BDBM50038412
Substrate
n/a
Meas. Tech.
ChEMBL_1455608 (CHEMBL3365309)
IC50
5000±n/a nM
Citation
 Guglielmo, S; Cortese, D; Vottero, F; Rolando, B; Kommer, VP; Williams, DL; Fruttero, R; Gasco, A New praziquantel derivatives containing NO-donor furoxans and related furazans as active agents against Schistosoma mansoni. Eur J Med Chem 84:135-45 (2014) [PubMed]  Article 
Target
Name:
Thioredoxin glutathione reductase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
64881.48
Organism:
Schistosoma mansoni
Description:
ChEMBL_1455608
Residue:
597
Sequence:
MPPADGTSQWLRKTVDSAAVILFSKTTCPYCKKVKDVLAEAKIKHATIELDQLSNGSAIQKCLASFSKIETVPQMFVRGKFIGDSQTVLKYYSNDELAGIVNESKYDYDLIVIGGGSGGLAAGKEAAKYGAKTAVLDYVEPTPIGTTWGLGGTCVNVGCIPKKLMHQAGLLSHALEDAEHFGWSLDRSKISHNWSTMVEGVQSHIGSLNWGYKVALRDNQVTYLNAKGRLISPHEVQITDKNQKVSTITGNKIILATGERPKYPEIPGAVEYGITSDDLFSLPYFPGKTLVIGASYVALECAGFLASLGGDVTVMVRSILLRGFDQQMAEKVGDYMENHGVKFAKLCVPDEIKQLKVVDTENNKPGLLLVKGHYTDGKKFEEEFETVIFAVGREPQLSKVLCETVGVKLDKNGRVVCTDDEQTTVSNVYAIGDINAGKPQLTPVAIQAGRYLARRLFAGATELTDYSNVATTVFTPLEYGACGLSEEDAIEKYGDKDIEVYHSNFKPLEWTVAHREDNVCYMKLVCRKSDNMRVLGLHVLGPNAGEITQGYAVAIKMGATKADFDRTIGIHPTCSETFTTLHVTKKSGVSPIVSGCG
  
Inhibitor
Name:
BDBM50038412
Synonyms:
2-Oxy-4-phenyl-furazan-3-carbonitrile | 3-cyano-4-phenyl-1,2,5-oxadiazole 2-oxide | CHEMBL336467 | furoxan
Type:
Small organic molecule
Emp. Form.:
C9H5N3O2
Mol. Mass.:
187.1549
SMILES:
[O-][n+]1onc(c1C#N)-c1ccccc1
Structure:
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