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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50053683
Substrate
n/a
Meas. Tech.
ChEMBL_1446971 (CHEMBL3373728)
Ki
0.010000±n/a nM
Citation
 Abdel-Magid, AF Pim kinase inhibitors for the treatment of cancer and possibly more. ACS Med Chem Lett 5:730-1 (2014) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50053683
Synonyms:
CHEMBL3318854 | US9328106, 135
Type:
Small organic molecule
Emp. Form.:
C20H21F3N6O2S
Mol. Mass.:
466.48
SMILES:
Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1[C@@H]1C[C@@H](F)[C@H](N)CCO1 |r|
Structure:
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