Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50267694
Substrate
n/a
Meas. Tech.
ChEMBL_1456829 (CHEMBL3367562)
Ki
47±n/a nM
Citation
 Salerno, L; Pittalą, V; Modica, MN; Siracusa, MA; Intagliata, S; Cagnotto, A; Salmona, M; Kurczab, R; Bojarski, AJ; Romeo, G Structure-activity relationships and molecular modeling studies of novel arylpiperazinylalkyl 2-benzoxazolones and 2-benzothiazolones as 5-HT(7) and 5-HT(1A) receptor ligands. Eur J Med Chem 85:716-26 (2014) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM50267694
Synonyms:
1-{4-[4-(1-Naphthyl)piperazin-1-yl]butyl}-1,3-dihydro-2H-indol-2-one | CHEMBL489028
Type:
Small organic molecule
Emp. Form.:
C26H29N3O
Mol. Mass.:
399.528
SMILES:
O=C1Cc2ccccc2N1CCCCN1CCN(CC1)c1cccc2ccccc12
Structure:
Search PDB for entries with ligand similarity: