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Target
2-acylglycerol O-acyltransferase 2
Ligand
BDBM50058841
Substrate
n/a
Meas. Tech.
ChEMBL_1452422 (CHEMBL3362084)
IC50
479±n/a nM
Citation
 Abdel-Magid, AF MoGAT-2 Inhibitors May Provide Effective Treatment for Hypertriglyceridemia. ACS Med Chem Lett 5:840-1 (2014) [PubMed]  Article 
Target
Name:
2-acylglycerol O-acyltransferase 2
Synonyms:
2-acylglycerol O-acyltransferase 2 | Acyl-CoA:monoacylglycerol acyltransferase 2 | Acyl-CoA:monoacylglycerol acyltransferase 2 (MOGAT2) | DC5 | DGAT2L5 | Diacylglycerol O-acyltransferase candidate 5 | Diacylglycerol acyltransferase 2-like protein 5 | MGAT2 | MOGAT2 | MOGT2_HUMAN | Monoacylglycerol Acyltransferase 2 (MGAT2) | Monoacylglycerol O-acyltransferase 2 | hDC5 | hMGAT2
Type:
Enzyme
Mol. Mass.:
38210.80
Organism:
Homo sapiens (Human)
Description:
Q3SYC2
Residue:
334
Sequence:
MVEFAPLFMPWERRLQTLAVLQFVFSFLALAEICTVGFIALLFTRFWLLTVLYAAWWYLDRDKPRQGGRHIQAIRCWTIWKYMKDYFPISLVKTAELDPSRNYIAGFHPHGVLAVGAFANLCTESTGFSSIFPGIRPHLMMLTLWFRAPFFRDYIMSAGLVTSEKESAAHILNRKGGGNLLGIIVGGAQEALDARPGSFTLLLRNRKGFVRLALTHGAPLVPIFSFGENDLFDQIPNSSGSWLRYIQNRLQKIMGISLPLFHGRGVFQYSFGLIPYRRPITTVVGKPIEVQKTLHPSEEEVNQLHQRYIKELCNLFEAHKLKFNIPADQHLEFC
  
Inhibitor
Name:
BDBM50058841
Synonyms:
CHEMBL3325735
Type:
Small organic molecule
Emp. Form.:
C19H26ClN3O3S
Mol. Mass.:
411.946
SMILES:
Cl.C[C@@H](NS(C)(=O)=O)c1ccc(CNCC2COc3ccccc3N2)cc1 |r|
Structure:
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