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Target
Beta-2 adrenergic receptor
Ligand
BDBM50060974
Substrate
n/a
Meas. Tech.
ChEMBL_1461172 (CHEMBL3395622)
Kd
5.1±n/a nM
Citation
 Soriano-Ursúa, MA; Arias-Montaño, JA; Correa-Basurto, J; Hernández-Martínez, CF; López-Cabrera, Y; Castillo-Hernández, MC; Padilla-Martínez, II; Trujillo-Ferrara, JG Insights on the role of boron containing moieties in the design of new potent and efficient agonists targeting theß2 adrenoceptor. Bioorg Med Chem Lett 25:820-5 (2015) [PubMed]  Article 
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2_CAVPO | Adrb2 | adrenergic Beta2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46993.24
Organism:
GUINEA PIG
Description:
adrenergic Beta2 ADRB2 GUINEA PIG::Q8K4Z4
Residue:
418
Sequence:
MGHLGNGSDFLLAPNASHAPDHNVTRERDEAWVVGMAIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMNMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVVILMVWVVSGLTSFLPIQMHWYRATHKDAINCYAEETCCDFFTNQAYAIASSIVSFYLPLVVMVFVYSRVFQVAKKQLQKIDRSEGRFHTQNLSQVEQDGRSGHGLRRSSKFYLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIPKEVYILLNWVGYVNSAFNPLIYCRSPDFRIAFQELLCLRRSALKAYGNDCSSNSNGKTDYTGEPNVCHQGQEKERELLCEDPPGTEDLVSCPGTVPSDSIDSQGRNYSTNDSLL
  
Inhibitor
Name:
BDBM50060974
Synonyms:
CHEMBL3393402
Type:
Small organic molecule
Emp. Form.:
C17H30BNO4
Mol. Mass.:
323.235
SMILES:
CC(C)C[B-]1(O)OCc2cc(ccc2O1)[C@@H](O)C[NH2+]C(C)(C)C |r|
Structure:
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