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Target
Kappa-type opioid receptor
Ligand
BDBM50061384
Substrate
n/a
Meas. Tech.
ChEMBL_1461561 (CHEMBL3396802)
EC50
1440±n/a nM
Citation
 Sasmal, PK; Krishna, CV; Adabala, SS; Roshaiah, M; Rawoof, KA; Thadi, E; Sukumar, KP; Cheera, S; Abbineni, C; Rao, KV; Prasanthi, A; Nijhawan, K; Jaleel, M; Iyer, LR; Chaitanya, TK; Tiwari, NK; Krishna, NL; Potluri, V; Khanna, I; Frimurer, TM; Lückmann, M; Rist, Ø; Elster, L; Högberg, T Optimisation of in silico derived 2-aminobenzimidazole hits as unprecedented selective kappa opioid receptor agonists. Bioorg Med Chem Lett 25:887-92 (2015) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM50061384
Synonyms:
CHEMBL3394001
Type:
Small organic molecule
Emp. Form.:
C17H20N6O
Mol. Mass.:
324.3803
SMILES:
O=C(Nc1nc2ccccc2n1CCN1CCCC1)c1ccn[nH]1
Structure:
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