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Target
Presenilin-1
Ligand
BDBM50062736
Substrate
n/a
Meas. Tech.
ChEMBL_1462966 (CHEMBL3398676)
EC50
4400±n/a nM
Citation
 Flesch, D; Ness, J; Lamers, C; Dehm, F; Popella, S; Steri, R; Ogorek, I; Hieke, M; Dannhardt, G; Werz, O; Weggen, S; Schubert-Zsilavecz, M SAR-studies of -secretase modulators with PPAR -agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease. Bioorg Med Chem Lett 25:841-6 (2015) [PubMed]  Article 
Target
Name:
Presenilin-1
Synonyms:
PS1-CTF12 | PS-1 | 3.4.23.- | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | PSEN1 | Protein S182 | PS1 | AD3 | Gamma-Secretase Subunit Presenilin-1 | PSNL1 | PSN1_HUMAN
Type:
n/a
Mol. Mass.:
52657.13
Organism:
Human
Description:
P49768
Residue:
467
Sequence:
MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
  
Inhibitor
Name:
BDBM50062736
Synonyms:
CHEMBL3397712
Type:
Small organic molecule
Emp. Form.:
C32H35F3O4
Mol. Mass.:
540.25
SMILES:
CCCC\C(=C/c1cc(OCc2ccc(CCCC)cc2)ccc1OCc1ccc(cc1)C(F)(F)F)C(O)=O
Structure:
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