Reaction Details Report a problem with these data
Target
Probable G-protein coupled receptor 88
Ligand
BDBM50064759
Substrate
n/a
Meas. Tech.
ChEMBL_1465054 (CHEMBL3405070)
EC50
170±n/a nM
Citation
 Dzierba, CD; Bi, Y; Dasgupta, B; Hartz, RA; Ahuja, V; Cianchetta, G; Kumi, G; Dong, L; Aleem, S; Fink, C; Garcia, Y; Green, M; Han, J; Kwon, S; Qiao, Y; Wang, J; Zhang, Y; Liu, Y; Zipp, G; Liang, Z; Burford, N; Ferrante, M; Bertekap, R; Lewis, M; Cacace, A; Grace, J; Wilson, A; Nouraldeen, A; Westphal, R; Kimball, D; Carson, K; Bronson, JJ; Macor, JE Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88. Bioorg Med Chem Lett 25:1448-52 (2015) [PubMed]  Article 
Target
Name:
Probable G-protein coupled receptor 88
Synonyms:
GPR88 | GPR88_HUMAN | Probable G-protein coupled receptor 88 | STRG | Striatum-specific G-protein coupled receptor
Type:
PROTEIN
Mol. Mass.:
40264.74
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109566
Residue:
384
Sequence:
MTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW
  
Inhibitor
Name:
BDBM50064759
Synonyms:
CHEMBL3403788
Type:
Small organic molecule
Emp. Form.:
C24H33NO3
Mol. Mass.:
383.5237
SMILES:
CC[C@H](C)COc1cc(C)c([C@H](CO)NC(=O)[C@@H](C)c2ccccc2)c(C)c1 |r|
Structure:
Search PDB for entries with ligand similarity: