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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM16661
Substrate
n/a
Meas. Tech.
ChEMBL_1464323 (CHEMBL3404590)
IC50
3260±n/a nM
Citation
 Al-Rashida, M; Ejaz, SA; Ali, S; Shaukat, A; Hamayoun, M; Ahmed, M; Iqbal, J Diarylsulfonamides and their bioisosteres as dual inhibitors of alkaline phosphatase and carbonic anhydrase: Structure activity relationship and molecular modelling studies. Bioorg Med Chem 23:2435-44 (2015) [PubMed]  Article 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | AP-TNAP | Alkaline phosphatase liver/bone/kidney isozyme | Alkaline phosphatase, tissue-nonspecific isozyme | PPBT_BOVIN | TNSALP | Tissue non-specific alkaline phosphatase (TNAP)
Type:
Protein
Mol. Mass.:
57195.60
Organism:
Bos taurus (Cattle)
Description:
P09487
Residue:
524
Sequence:
MISPFLLLAIGTCFASSLVPEKEKDPKYWRDQAQQTLKNALRLQTLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHSPGEETKLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSASYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIKDIEVIMGGGRKYMFPKNRTDVEYELDEKARGTRLDGLNLIDIWKSFKPKHKHSHYVWNRTDLLALDPHSVDYLLGLFEPGDMQYELNRNNATDPSLSEMVEMAIRILNKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIGQAGAMTSVEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYAACIGANRDHCASASSSGSPSPGPLLLLLALLPLGSLF
  
Inhibitor
Name:
BDBM16661
Synonyms:
1-N-(4-fluorobenzene)benzene-1,4-disulfonamide | aromatic sulfonamide compound 26
Type:
Small organic molecule
Emp. Form.:
C12H11FN2O4S2
Mol. Mass.:
330.355
SMILES:
NS(=O)(=O)c1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1
Structure:
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